Sugi Predict

Sugi Predict / Compounds / SCHEMBL7181623

SCHEMBL7181623

SCHEMBL7181623

Cc1cc(C)c(C(=O)[PH](=O)c2c(C)c(C)c(C)c(C(=O)c3ccccc3)c2C)c(C)c1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 1/20 0.37
▸ GFER P55789 1/20 0.36
▸ ALDH1A1 P00352 7/20 0.35
▸ MAPT P10636 5/20 0.35
▸ LMNA P02545 3/20 0.35
▸ BCL2L1 Q07817 1/20 0.35
▸ ATM Q13315 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ GRM6 O15303 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ GAA P10253 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ HPGD P15428 2/20 0.33
▸ PLA2G1B P04054 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ ATG4B Q9Y4P1 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ CES2 O00748 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180474 0.97 HTT (0.38) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7180520 0.90 ALDH1A1 (0.36) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7180036 0.89 KMT2A (0.37) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7177292 0.86 HTT (0.38) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7188524 0.86 KMT2A (0.38) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7181622 0.86 NPSR1 (0.34) GFERALDH1A1MAPTLMNABCL2L1
SCHEMBL7175881 0.86 LMNA (0.36) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7181463 0.85 HPGD (0.36) HTTGFERALDH1A1MAPTLMNA
SCHEMBL7180951 0.84 ALDH1A1 (0.34) HTTALDH1A1MAPTLMNABCL2L1
SCHEMBL7182859 0.83 NPSR1 (0.36) HTTALDH1A1MAPTLMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 HTT 2802/4885GFER 946/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 HTT 2393/4885GFER 658/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.