Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182859

SCHEMBL7182859

SCHEMBL7182859

Cc1cc(C)c(C(=O)[PH](=O)c2c(C)ccc(C(=O)c3ccccc3)c2C)c(C)c1C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.36
▸ ALDH1A1 P00352 4/20 0.36
▸ KDM4E B2RXH2 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ KEAP1 Q14145 1/20 0.35
▸ NFE2L2 Q16236 1/20 0.35
▸ PTGS2 P35354 1/20 0.35
▸ MAPK1 P28482 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ PGR P06401 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ SLC6A2 P23975 1/20 0.35
▸ PDE4A P27815 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ HRH1 P35367 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180492 0.89 NPSR1 (0.40) NPSR1ALDH1A1KDM4EMEN1USP2
SCHEMBL7181622 0.88 NPSR1 (0.34) NPSR1ALDH1A1KDM4EMEN1USP2
SCHEMBL7180520 0.87 ALDH1A1 (0.36) ALDH1A1KDM4EMEN1GAAKMT2A
SCHEMBL7180474 0.85 HTT (0.38) NPSR1ALDH1A1KDM4EMEN1GAA
SCHEMBL7182363 0.85 TDP1 (0.39) NPSR1ALDH1A1KDM4EMEN1USP2
SCHEMBL7177222 0.83 TP53 (0.37) ALDH1A1KDM4EMEN1USP2GAA
SCHEMBL7182229 0.83 MEN1 (0.37) NPSR1ALDH1A1KDM4EMEN1USP2
SCHEMBL7181623 0.83 HTT (0.37) NPSR1ALDH1A1KDM4EMEN1GAA
SCHEMBL7179789 0.82 LMNA (0.40) NPSR1ALDH1A1MEN1USP2GAA
SCHEMBL7182652 0.82 PTGS2 (0.35) ALDH1A1KDM4EMEN1USP2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 NPSR1 2669/4885ALDH1A1 3416/4885KDM4E 3226/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 NPSR1 3007/4885ALDH1A1 3984/4885KDM4E 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.