Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11678721 | 0.84 | ALDH1A1 (0.37) | PGK1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11675190 | 0.83 | PGK1 (0.48) | PGK1ALDH1A1MAPTTLR7NPC1 | |
| SCHEMBL11679118 | 0.81 | PDE4A (0.38) | ALDH1A1PIN1MAPTMEN1KMT2A | |
| SCHEMBL11676864 | 0.81 | DPP4 (0.40) | PGK1ALDH1A1TSHRPOLBMAPT | |
| SCHEMBL10083724 | 0.79 | TSHR (0.34) | ALDH1A1TSHRPIN1POLBMAPT | |
| SCHEMBL10074072 | 0.79 | HASPIN (0.40) | PGK1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11676507 | 0.78 | KMT2A (0.50) | PGK1POLBMEN1KMT2ATLR7 | |
| Propane SCHEMBL28499124 | 0.78 | ALDH1A1 (0.33) | PGK1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11680812 | 0.77 | KMT2A (0.39) | PGK1ALDH1A1POLBMAPTMEN1 | |
| SCHEMBL4846686 | 0.76 | POLB (0.32) | PIN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170224699-A1 | NOVEL IMMUNE SYSTEM MODULATORS | Wilmer Cutler Pickering Hale and Dorr LLP | 2017-08-10 | — | — | US | disclosed |
| US-9637489-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9359361-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-20160074403-A1 | NOVEL IMMUNE SYSTEM MODULATORS | Wilmer Cutler Pickering Hale and Dorr LLP | 2016-03-17 | — | — | US | disclosed |
| US-9126996-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20140221646-A1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140079724-A1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| EP-0300726-B1 | PIPERAZINYL DERIVATES OF PURINES AND ISOSTERES THEREOF AS HYPOGLYCEMIC AGENTS | MERCK & CO. INC. (US) | 1993-09-22 | — | — | EP | disclosed |
| US-5057517-A | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents | MERCK & CO., INC. (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0300726-A1 | Piperazinyl derivates of purines and isosteres thereof as hypoglycemic agents | MERCK & CO. INC. (US) | 1989-01-25 | — | — | EP | disclosed |
| US-4014677-A | HERBICIDES | CIBA-GEIGY CORPORATION (US) | 1977-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140079724-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | PGK1 4510/4885GRIN2D 4061/4885GRIN3B 1334/4885 |
| US-20140221646-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | PGK1 4510/4885GRIN2D 4061/4885GRIN3B 1334/4885 |
| US-20160074403-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | PGK1 4510/4885GRIN2D 4061/4885GRIN3B 1334/4885 |
| US-20170224699-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | PGK1 4510/4885GRIN2D 4061/4885GRIN3B 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.