Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.58 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP8 | P22894 | 4/20 | 0.44 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | MMP12 | P39900 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7181905 | 1.00 | MMP13 (0.58) | MMP13MMP2MMP8MMP9MMP12 | |
| SCHEMBL7184281 | 0.90 | MMP13 (0.74) | MMP13MMP2MMP8MMP1MMP3 | |
| SCHEMBL7183683 | 0.84 | MMP13 (0.79) | MMP13MMP2MMP8MMP1MMP3 | |
| SCHEMBL7183687 | 0.84 | MMP13 (0.79) | MMP13MMP2MMP8MMP1MMP3 | |
| SCHEMBL7187623 | 0.78 | MMP13 (0.47) | MMP13MMP2MMP1CA12CA1 | |
| SCHEMBL7185986 | 0.75 | MMP13 (0.82) | MMP13CA2 | |
| SCHEMBL7185980 | 0.75 | MMP13 (0.82) | MMP13CA2 | |
| SCHEMBL7185940 | 0.75 | MMP13 (0.67) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL7185942 | 0.75 | MMP13 (0.67) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL7186097 | 0.74 | MMP13 (1.00) | MMP13MMP2MMP8MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583299-B1 | Matrix metalloprotease inhibitors; nonsuppression of tumor necrosis factor production | G.D. SEARLE & CO. | 2003-06-24 | — | — | US | disclosed |
| EP-1178959-A1 | ALPHA-AMINO-BETA-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071514-A1 | α-AMINO-β-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2000-11-30 | — | — | WO | disclosed |