Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.82 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185980 | 1.00 | MMP13 (0.82) | MMP13CA2PPARACASP1PPARG | |
| SCHEMBL7185942 | 0.90 | MMP13 (0.67) | MMP13CA2CASP1 | |
| SCHEMBL7185940 | 0.90 | MMP13 (0.67) | MMP13CA2CASP1 | |
| SCHEMBL7180333 | 0.85 | MMP13 (0.82) | MMP13CASP1CTSSCTSK | |
| SCHEMBL7183683 | 0.82 | MMP13 (0.79) | MMP13 | |
| SCHEMBL7183687 | 0.82 | MMP13 (0.79) | MMP13 | |
| SCHEMBL22783671 | 0.79 | PPARA (0.53) | MMP13CA2PPARACASP1PPARG | |
| SCHEMBL2749553 | 0.78 | PPARA (0.53) | MMP13CA2PPARACASP1PPARG | |
| SCHEMBL7349434 | 0.78 | CA12 (0.57) | MMP13CA2PPARACASP1PPARG | |
| SCHEMBL9686663 | 0.78 | CA12 (0.57) | MMP13CA2PPARACASP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583299-B1 | Matrix metalloprotease inhibitors; nonsuppression of tumor necrosis factor production | G.D. SEARLE & CO. | 2003-06-24 | — | — | US | disclosed |
| EP-1178959-A1 | ALPHA-AMINO-BETA-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071514-A1 | α-AMINO-β-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2000-11-30 | — | — | WO | disclosed |