Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182211

SCHEMBL7182211

SCHEMBL7182211

O=C(c1c(Cl)cccc1Cl)[PH](=O)CCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 1/20 0.43
▸ KEAP1 Q14145 1/20 0.43
▸ SCN5A Q14524 1/20 0.42
▸ SCN2A Q99250 1/20 0.42
▸ NPC1 O15118 2/20 0.42
▸ RAB9A P51151 2/20 0.42
▸ FFAR1 O14842 4/20 0.41
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ FEN1 P39748 1/20 0.40
▸ POLB P06746 1/20 0.39
▸ TRPM8 Q7Z2W7 1/20 0.39
▸ LMNA P02545 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ PLAAT3 P53816 1/20 0.38
▸ PLAAT5 Q96KN8 1/20 0.38
▸ PLAAT2 Q9NWW9 1/20 0.38
▸ PLAAT4 Q9UL19 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189390 0.91 SCN5A (0.46) P2RX7KEAP1SCN5ASCN2ANPC1
SCHEMBL7182858 0.90 GPR52 (0.45) P2RX7KEAP1SCN5ASCN2ANPC1
SCHEMBL7183615 0.89 SCN5A (0.48) P2RX7KEAP1SCN5ASCN2ANPC1
SCHEMBL7190488 0.88 SCN5A (0.47) P2RX7SCN5ASCN2AALDH1A1POLB
SCHEMBL7175990 0.88 SCN5A (0.47) P2RX7SCN5ASCN2AALDH1A1POLB
SCHEMBL7183532 0.88 SCN5A (0.47) P2RX7SCN5ASCN2AALDH1A1POLB
SCHEMBL7188235 0.88 SCN5A (0.47) P2RX7SCN5ASCN2AALDH1A1POLB
SCHEMBL7180510 0.88 SCN5A (0.47) P2RX7SCN5ASCN2AALDH1A1POLB
SCHEMBL7188707 0.86 TAAR1 (0.50) RAB9AFFAR1MEN1KMT2AALDH1A1
SCHEMBL7189920 0.83 ALDH1A1 (0.42) P2RX7SCN5ASCN2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 P2RX7 4680/4885KEAP1 2886/4885SCN5A 1196/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 P2RX7 4753/4885KEAP1 2402/4885SCN5A 2114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.