Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189920

SCHEMBL7189920

SCHEMBL7189920

O=C(c1c(Cl)cccc1Cl)[PH](=O)Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.42
▸ FEN1 P39748 1/20 0.42
▸ TRPM8 Q7Z2W7 1/20 0.40
▸ AKR1B1 P15121 1/20 0.39
▸ TXNRD1 Q16881 1/20 0.39
▸ P2RX7 Q99572 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ SCN5A Q14524 1/20 0.38
▸ SCN2A Q99250 1/20 0.38
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ PBRM1 Q86U86 1/20 0.37
▸ KMT2A Q03164 4/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ HPGD P15428 2/20 0.37
▸ MITF O75030 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ XBP1 P17861 1/20 0.37
▸ NFKB1 P19838 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189041 0.89 GPR52 (0.40) ALDH1A1FEN1TRPM8L3MBTL1SMN1; SMN2
SCHEMBL7185623 0.85 TAAR1 (0.46) ALDH1A1NPC1RAB9AKMT2AMEN1
SCHEMBL7182211 0.83 P2RX7 (0.43) ALDH1A1FEN1TRPM8TXNRD1P2RX7
SCHEMBL7189390 0.81 SCN5A (0.46) P2RX7TDP1SCN5ASCN2ANPC1
SCHEMBL7183615 0.80 SCN5A (0.48) P2RX7SCN5ASCN2ANPC1RAB9A
SCHEMBL7175024 0.79 GPR52 (0.45) TRPM8P2RX7TDP1L3MBTL1NPC1
SCHEMBL7175990 0.79 SCN5A (0.47) ALDH1A1P2RX7TDP1SCN5ASCN2A
SCHEMBL7188235 0.79 SCN5A (0.47) ALDH1A1P2RX7TDP1SCN5ASCN2A
SCHEMBL7183532 0.79 SCN5A (0.47) ALDH1A1P2RX7TDP1SCN5ASCN2A
SCHEMBL7180510 0.79 SCN5A (0.47) ALDH1A1P2RX7TDP1SCN5ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885FEN1 2544/4885TRPM8 3322/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885FEN1 2512/4885TRPM8 3576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.