Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182364

SCHEMBL7182364

SCHEMBL7182364

Cc1cccc(C)c1PC(=O)c1c(C(F)(F)F)cccc1C(F)(F)F.[LiH]

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 2/20 0.36
▸ TDP1 Q9NUW8 3/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ GAA P10253 2/20 0.36
▸ ATM Q13315 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ TAS2R14 Q9NYV8 1/20 0.35
▸ ALOX12 P18054 1/20 0.35
▸ RORC P51449 2/20 0.35
▸ HDAC4 P56524 1/20 0.34
▸ TYK2 P29597 1/20 0.34
▸ GABRA1 P14867 1/20 0.33
▸ GABRB2 P47870 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ PLK1 P53350 1/20 0.33
▸ PLK3 Q9H4B4 1/20 0.33
▸ NFKB1 P19838 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7181268 0.89 SMN1; SMN2 (0.39) NOTUMALDH1A1NPSR1TAS2R14ALOX12
SCHEMBL7174618 0.87 ACHE (0.37) NOTUMGAATAS2R14HDAC4GABRA1
SCHEMBL7176993 0.84 GAA (0.37) NOTUMTDP1ALDH1A1KDM4EGAA
Lithium SCHEMBL7177000 0.81 GAA (0.37) NOTUMTDP1ALDH1A1KDM4EGAA
SCHEMBL7180411 0.81 L3MBTL1 (0.38) NOTUMTDP1ALDH1A1KDM4EATM
SCHEMBL7184683 0.79 MEN1 (0.39) NOTUMTDP1ALDH1A1KDM4EATM
SCHEMBL7186814 0.78 SMN1; SMN2 (0.37) NOTUMTDP1ALDH1A1KDM4EATM
SCHEMBL7175826 0.78 ALDH1A1 (0.39) NOTUMTDP1ALDH1A1KDM4EATM
SCHEMBL7189867 0.77 HDAC4 (0.39) ALDH1A1KDM4EGAATAS2R14HDAC4
SCHEMBL7182754 0.76 ALDH1A1 (0.45) ALDH1A1GAAHDAC4TYK2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 NOTUM 1188/4885TDP1 4234/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 NOTUM 853/4885TDP1 4275/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.