Sugi Predict

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SCHEMBL7182647

SCHEMBL7182647

COc1ccc(Cl)c(OC)c1C(=O)P(=O)(C(=O)c1c(C)cc(C(C)(C)C)cc1C)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ TAS1R3 Q7RTX0 5/20 0.38
▸ TAS1R1 Q7RTX1 5/20 0.38
▸ TAS1R2 Q8TE23 4/20 0.38
▸ MAPT P10636 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ TP53 P04637 1/20 0.36
▸ NR1H4 Q96RI1 2/20 0.36
▸ GRM4 Q14833 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ TOP1 P11387 1/20 0.35
▸ LMNA P02545 2/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.35
▸ GAA P10253 1/20 0.35
▸ TSHR P16473 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7178030 0.92 ALDH1A1 (0.45) ALDH1A1KDM4EHSD17B10KMT2ATAS1R3
SCHEMBL7190262 0.91 MAPT (0.39) ALDH1A1KDM4EKMT2AMAPTSMN1; SMN2
SCHEMBL7182506 0.90 TAS1R3 (0.45) ALDH1A1KDM4EHSD17B10KMT2ATAS1R3
SCHEMBL7181250 0.89 TAS1R3 (0.39) ALDH1A1KDM4EHSD17B10KMT2ATAS1R3
SCHEMBL7178072 0.88 ALDH1A1 (0.43) ALDH1A1KDM4EHSD17B10KMT2ATAS1R3
SCHEMBL7188507 0.87 SMN1; SMN2 (0.38) KMT2AMAPTSMN1; SMN2TP53NR1H4
SCHEMBL7188953 0.87 FABP4 (0.38) ALDH1A1KDM4EKMT2AMAPTSMN1; SMN2
SCHEMBL7174659 0.86 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10KMT2ATAS1R3
SCHEMBL7184400 0.85 CA12 (0.42) ALDH1A1KDM4EKMT2ATAS1R3TAS1R1
SCHEMBL7189138 0.84 POLB (0.40) ALDH1A1KDM4EHSD17B10KMT2ATAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885KDM4E 3226/4885HSD17B10 56/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885KDM4E 2651/4885HSD17B10 42/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.