Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182786

SCHEMBL7182786

SCHEMBL7182786

Cc1cccc(Cl)c1C(=O)C(C(=O)OCc1ccccc1)c1ccccc1.O=[PH3]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 1/20 0.43
▸ LMNA P02545 2/20 0.41
▸ NPC1 O15118 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ OPRK1 P41145 2/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ MAPT P10636 1/20 0.40
▸ PTPN7 P35236 1/20 0.40
▸ OPRM1 P35372 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ DUSP3 P51452 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ L3MBTL1 Q9Y468 2/20 0.40
▸ MMP8 P22894 1/20 0.39
▸ CASP3 P42574 2/20 0.37
▸ ITGB1 P05556 2/20 0.36
▸ ITGA4 P13612 2/20 0.36
▸ ITGA2 P17301 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27484210 0.95 ELANE (0.43) ELANELMNANPC1RAB9AALDH1A1
SCHEMBL7185526 0.91 ELANE (0.44) ELANELMNAALDH1A1OPRK1MEN1
SCHEMBL7175658 0.91 NPC1 (0.45) ELANELMNANPC1RAB9AALDH1A1
SCHEMBL7184953 0.89 MMP8 (0.50) LMNANPC1RAB9AALDH1A1MEN1
SCHEMBL27500265 0.86 NPC1 (0.45) ELANENPC1RAB9AALDH1A1MEN1
SCHEMBL7182121 0.86 ELANE (0.41) ELANELMNANPC1RAB9AALDH1A1
SCHEMBL7174628 0.86 ALDH1A1 (0.40) LMNANPC1RAB9AALDH1A1MEN1
SCHEMBL7182317 0.86 MMP8 (0.41) LMNANPC1RAB9AALDH1A1MAPT
SCHEMBL7185347 0.85 L3MBTL1 (0.43) LMNANPC1RAB9AALDH1A1MEN1
SCHEMBL27499665 0.84 MMP8 (0.50) LMNANPC1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ELANE 4357/4885LMNA 3241/4885NPC1 772/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ELANE 4460/4885LMNA 3247/4885NPC1 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.