Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1204829 | 0.85 | KAT2B (0.70) | ALDH1A1NPSR1KAT2BMAPTLMNA | |
| SCHEMBL31069460 | 0.85 | KAT2B (0.70) | ALDH1A1NPSR1KAT2BMAPTLMNA | |
| SCHEMBL29519350 | 0.82 | KAT2B (0.70) | ALDH1A1KAT2BMAPTLMNAPKM | |
| SCHEMBL112161 | 0.82 | KAT2B (0.70) | ALDH1A1KAT2BMAPTLMNAPKM | |
| SCHEMBL9759799 | 0.82 | ALDH1A1 (0.71) | ALDH1A1NPSR1KAT2BMAPTLMNA | |
| SCHEMBL2080430 | 0.82 | KAT2B (0.65) | ALDH1A1KAT2BMAPTLMNAPKM | |
| SCHEMBL26913572 | 0.82 | KAT2B (0.65) | ALDH1A1KAT2BMAPTLMNAPKM | |
| SCHEMBL2866187 | 0.82 | KAT2B (0.65) | ALDH1A1NPSR1KAT2BMAPTLMNA | |
| SCHEMBL1594797 | 0.81 | ALDH1A1 (0.72) | ALDH1A1NPSR1KAT2BMAPTLMNA | |
| SCHEMBL9725410 | 0.81 | ALDH1A1 (0.72) | ALDH1A1NPSR1KAT2BMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-5162318-A | Which have pulmonary surfactant secretion promoting activity | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| EP-0454330-A1 | Benzimidazolinone derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1991-10-30 | — | — | EP | disclosed |