Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | BCHE | P06276 | 2/20 | 0.58 |
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208819 | 0.92 | SMN1; SMN2 (0.69) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 | |
| SCHEMBL8107611 | 0.86 | MAPT (0.60) | ALDH1A1BCHEACHESMN1; SMN2MAPT | |
| SCHEMBL1594633 | 0.86 | MAPT (0.56) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 | |
| SCHEMBL26640796 | 0.85 | MAPT (0.58) | ALDH1A1NPSR1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL9725410 | 0.85 | ALDH1A1 (0.72) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 | |
| SCHEMBL30221510 | 0.84 | ALDH1A1 (0.56) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 | |
| SCHEMBL1595477 | 0.84 | ALDH1A1 (0.56) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 | |
| SCHEMBL3143350 | 0.84 | POLB (0.61) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 | |
| SCHEMBL6815730 | 0.84 | ALDH1A1 (0.63) | ALDH1A1NPSR1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL26640672 | 0.84 | ALDH1A1 (0.56) | ALDH1A1NPSR1BCHEACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190125882-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2019-05-02 | — | — | US | disclosed |
| US-10179175-B2 | Isatoic anhydride derivatives and applications thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2019-01-15 | — | — | US | disclosed |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2018-04-26 | — | — | US | disclosed |
| US-9867883-B2 | Isatoic anhydride derivatives and applications thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2018-01-16 | — | — | US | disclosed |
| EP-1224170-B9 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2017-11-22 | — | — | EP | disclosed |
| US-20170035893-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2017-02-09 | — | — | US | disclosed |
| US-7919510-B2 | treatment or prevention of chronic pain, acute pain, migraine, and neuropathic pain; selectively inhibits neuronal nitric oxide synthase (nNOS) over endothelial nitric oxide synthase (eNOS) and/or inducible nitric oxide synthase (iNOS) | NEURAXON, INC (CA) | 2011-04-05 | — | — | US | disclosed |
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| EP-1888568-A4 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS WITH DUAL NOS INHIBITORY ACTIVITY AND MUOPIOID AGONIST ACTIVITY | NEURAXON INC (CA) | 2009-08-12 | — | — | EP | disclosed |
| EP-1224170-B1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | EP | disclosed |
| CN-100455568-C | 6-position substituted indoline, production and use thereof as medicament | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-01-28 | — | — | CN | disclosed |
| US-20080214613-A1 | Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity | NEURAXON, INC (CA) | 2008-09-04 | — | — | US | disclosed |
| EP-1888568-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS WITH DUAL NOS INHIBITORY ACTIVITY AND MUOPIOID AGONIST ACTIVITY | Neuraxon Inc. (CA) | 2008-02-20 | — | — | EP | disclosed |
| WO-2007017764-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS WITH DUAL NOS INHIBITORY ACTIVITY AND MUOPIOID AGONIST ACTIVITY | NEURAXON, INC. (CA) | 2007-02-15 | — | — | WO | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |
| EP-1224170-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027081-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179175-B2 | Isatoic anhydride derivatives and applications thereof | AASDHPPT, CA13, CA12 | ALDH1A1 679/4885NPSR1 1366/4885BCHE 193/4885 |
| US-20190125882-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | ALDH1A1 679/4885NPSR1 1366/4885BCHE 193/4885 |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | ALDH1A1 679/4885NPSR1 1366/4885BCHE 193/4885 |
| US-20170035893-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | ALDH1A1 679/4885NPSR1 1366/4885BCHE 193/4885 |
| US-20080214613-A1 | Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity | OPRM1, NOS1, OPRK1 | ALDH1A1 1605/4885NPSR1 49/4885BCHE 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.