Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530802 | 0.81 | IMPDH2 (0.48) | IMPDH2TACR3ROCK2ROCK1PPARG | |
| SCHEMBL7592814 | 0.77 | HDAC6 (0.43) | MAPTGAAHPGDMEN1CASP3 | |
| SCHEMBL3039120 | 0.75 | POLB (0.58) | IMPDH2TACR3ROCK2ROCK1KCNK9 | |
| SCHEMBL7195286 | 0.74 | KMT2A (0.52) | MAPTGAAHPGDCNR2MEN1 | |
| SCHEMBL7674538 | 0.73 | SIRT2 (0.51) | PPARGHPGDRAB9AKMT2AHDAC1 | |
| SCHEMBL7182884 | 0.71 | NPC1 (0.48) | ROCK2ROCK1MAPTRAB9A | |
| SCHEMBL17585366 | 0.70 | POLB (0.53) | IMPDH2TACR3ROCK2KCNK9GAA | |
| SCHEMBL3836272 | 0.70 | RAB9A (0.57) | IMPDH2ROCK2KCNK9RAB9ACASP3 | |
| SCHEMBL94229 | 0.69 | IMPDH2 (0.52) | IMPDH2TACR3ROCK2ROCK1KCNK9 | |
| SCHEMBL3838597 | 0.69 | IMPDH2 (0.52) | IMPDH2TACR3ROCK2ROCK1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274676-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 1,4-QUINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | claimed |
| WO-2001079155-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 1,4-QUINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-25 | — | — | WO | claimed |