Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.47 |
| ▸ | FEN1 | P39748 | 2/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111106 | 0.90 | SLC22A12 (0.54) | ALOX5APFEN1RPS6KA3NR1H2NR1H3 | |
| SCHEMBL6736544 | 0.88 | NR1H2 (0.49) | ALOX5APFEN1RPS6KA3NR1H2NR1H3 | |
| SCHEMBL6728404 | 0.87 | RPS6KA3 (0.49) | ALOX5APFEN1RPS6KA3SLC22A12PTGS2 | |
| SCHEMBL7545909 | 0.86 | SLC22A12 (0.57) | ALOX5APFEN1RPS6KA3NR1H2NR1H3 | |
| SCHEMBL7045230 | 0.86 | RPS6KA3 (0.57) | ALOX5APFEN1RPS6KA3SLC22A12PTGS2 | |
| SCHEMBL7116024 | 0.85 | RPS6KA3 (0.64) | RPS6KA3NR1H2NR1H3SLC22A12PTGS2 | |
| SCHEMBL7041056 | 0.84 | PTGS2 (0.52) | RPS6KA3SLC22A12PTGS2PTGS1 | |
| SCHEMBL7042452 | 0.84 | RPS6KA3 (0.47) | ALOX5APFEN1RPS6KA3NR1H2NR1H3 | |
| SCHEMBL7537753 | 0.84 | RPS6KA3 (0.51) | RPS6KA3NR1H2NR1H3SLC22A12 | |
| SCHEMBL7111676 | 0.83 | PTGS2 (0.49) | ALOX5APFEN1RPS6KA3NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | PHARMACIA CORPORATION | 2002-12-05 | — | — | US | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183362-A1 | 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation | FPR2, FPR1, PTGES2 | ALOX5AP 454/4885FEN1 1649/4885RPS6KA3 1119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.