Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183929 | 0.82 | ALDH1A1 (0.42) | IRAK4 | |
| SCHEMBL7191728 | 0.79 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL7183015 | 0.78 | KDM4E (0.44) | MAPK8PRKD3MAP4K4MINK1TNIK | |
| SCHEMBL7185647 | 0.78 | KDM4E (0.44) | MAPK8PRKD3MAP4K4MINK1TNIK | |
| SCHEMBL2714609 | 0.69 | SYK (0.46) | IRAK4PDPK1 | |
| SCHEMBL24320354 | 0.69 | HTT (0.36) | MAPK8PRKD3IRAK4MAPK9PDPK1 | |
| SCHEMBL26913615 | 0.69 | HTT (0.36) | MAPK8PRKD3IRAK4MAPK9PDPK1 | |
| SCHEMBL25887394 | 0.68 | HTT (0.46) | MAP4K4PDPK1GRM5 | |
| SCHEMBL7187155 | 0.68 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL7187159 | 0.68 | IRAK4 (0.43) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |