Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444141 | 0.89 | SRD5A1 (0.53) | ESR2SRD5A1HTR3AMAPTALDH1A1 | |
| SCHEMBL28137635 | 0.85 | ESR2 (0.69) | ESR2SRD5A1HTR3AMAPTALDH1A1 | |
| SCHEMBL17996691 | 0.81 | ESR2 (0.50) | ESR2MAPTMAP1LC3BPDE4APDE4B | |
| SCHEMBL18980759 | 0.81 | ESR2 (0.50) | ESR2MAPTMAP1LC3BPDE4APDE4B | |
| SCHEMBL714856 | 0.81 | ESR2 (0.50) | ESR2MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3964037 | 0.81 | ESR2 (0.74) | ESR2MAPTCYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3668278 | 0.81 | ESR2 (0.50) | ESR2MAPTPDE4APDE4BPDE4C | |
| SCHEMBL715319 | 0.81 | ESR2 (0.50) | ESR2MAPTMAP1LC3BPDE4APDE4B | |
| SCHEMBL714528 | 0.81 | MAPT (0.59) | ESR2SRD5A1MAPTALDH1A1CYP2C9 | |
| SCHEMBL714527 | 0.81 | MAPT (0.59) | ESR2SRD5A1MAPTALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114574883-A | Method for deoxidizing, hydrogenating and deuterating alpha, beta-unsaturated aldehyde ketone into corresponding olefin and deuterated olefin | 南京中医药大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-108299334-B | Bicyclic sulfinamide-alkene chiral ligand, and preparation method and application thereof | 成都理工大学 | 2021-06-25 | — | — | CN | disclosed |
| EP-2816040-B1 | Process for the production of CCR2 receptor antagonists and intermediates thereof | CENTREXION THERAPEUTICS CORP (US) | 2018-10-17 | — | — | EP | disclosed |
| US-9751877-B2 | Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9751877-B2 | Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9751877-B2 | Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |
| EP-2897956-B1 | NOVEL BICYCLIC PYRIDINONES | PFIZER (US) | 2016-11-09 | — | — | EP | disclosed |
| EP-2897956-B1 | NOVEL BICYCLIC PYRIDINONES | PFIZER (US) | 2016-11-09 | — | — | EP | disclosed |
| US-20160024088-A1 | Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders | PFIZER INC. | 2016-01-28 | — | — | US | disclosed |
| US-20160024088-A1 | Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders | PFIZER INC. | 2016-01-28 | — | — | US | disclosed |
| US-8835440-B2 | Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-16 | — | — | US | disclosed |
| WO-2014045156-A1 | NOVEL BICYCLIC PYRIDINONES | PFIZER INC. (US) | 2014-03-27 | — | — | WO | disclosed |
| US-20140088111-A1 | Novel Bicyclic Pyridinones | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20140088111-A1 | Novel Bicyclic Pyridinones | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2014045156-A1 | NOVEL BICYCLIC PYRIDINONES | PFIZER INC. (US) | 2014-03-27 | — | — | WO | disclosed |
| US-20140088111-A1 | Novel Bicyclic Pyridinones | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20130324517-A1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-12-05 | — | — | US | disclosed |
| US-20120053164-A1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-03-01 | — | — | US | disclosed |
| EP-0433780-B1 | Substituted azolylmethylcycloalkanols and fungicides containing them | BASF AG (DE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0433780-A1 | Substituted azolylmethylcycloalkanols and fungicides containing them | BASF Aktiengesellschaft (DE) | 1991-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053164-A1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | CCR2, CCR1, CCR5 | ESR2 536/4885SRD5A1 2496/4885HTR3A 909/4885 |
| US-20140088111-A1 | Novel Bicyclic Pyridinones | CYP2B6, CYP2D6, CYP2C19 | ESR2 3844/4885SRD5A1 310/4885HTR3A 400/4885 |
| US-20160024088-A1 | Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders | PRNP, SNCA, PSEN1 | ESR2 4316/4885SRD5A1 1443/4885HTR3A 213/4885 |
| US-20130324517-A1 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD | CCR2, CCR5, CCR1 | ESR2 538/4885SRD5A1 4361/4885HTR3A 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.