Sugi Predict

Sugi Predict / Compounds / SCHEMBL7186804

SCHEMBL7186804

SCHEMBL7186804

Cc1cc(C)c(C(=O)P(=O)(C(=S)c2c(C)cccc2Cl)c2ccccc2)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.38
▸ LMNA P02545 3/20 0.38
▸ HTT P42858 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ ALDH1A1 P00352 3/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ TYK2 P29597 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ FABP3 P05413 1/20 0.35
▸ FABP4 P15090 1/20 0.35
▸ GAA P10253 3/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ ITGB1 P05556 2/20 0.35
▸ ITGA4 P13612 2/20 0.35
▸ ITGA2 P17301 1/20 0.35
▸ ITGB7 P26010 1/20 0.35
▸ TRPM4 Q8TD43 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7188244 0.94 TYK2 (0.41) MAPTKMT2AALDH1A1TYK2L3MBTL1
SCHEMBL7180603 0.91 TYK2 (0.41) MAPTKMT2AALDH1A1TYK2L3MBTL1
SCHEMBL7175917 0.91 TYK2 (0.41) MAPTKMT2AALDH1A1TYK2L3MBTL1
SCHEMBL7182411 0.90 KMT2A (0.40) MAPTLMNAHTTKMT2AMEN1
SCHEMBL7177897 0.90 MAPT (0.38) MAPTLMNAHTTALDH1A1SMN1; SMN2
SCHEMBL7183366 0.88 TYK2 (0.36) MAPTLMNAHTTKMT2AALDH1A1
SCHEMBL7181097 0.87 KMT2A (0.42) MAPTKMT2AMEN1ALDH1A1TYK2
SCHEMBL7180487 0.84 LMNA (0.37) MAPTLMNAHTTKMT2AMEN1
SCHEMBL7189057 0.83 ATM (0.41) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL7187975 0.83 ATM (0.41) LMNAKMT2AMEN1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MAPT 4870/4885LMNA 3241/4885HTT 2802/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MAPT 4859/4885LMNA 3247/4885HTT 2393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.