Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412375 | 0.77 | HDAC1 (0.50) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL7183359 | 0.73 | PTPN1 (0.44) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL7193590 | 0.71 | HDAC1 (0.43) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL10418379 | 0.70 | PTPN1 (0.61) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL11201642 | 0.69 | PTPN1 (0.56) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL7407613 | 0.68 | PIN1 (0.64) | PTPN1KMT2A | |
| SCHEMBL5899479 | 0.67 | PTPN1 (0.67) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL23782350 | 0.67 | SMN1; SMN2 (0.66) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL30173758 | 0.67 | SMN1; SMN2 (0.66) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 | |
| SCHEMBL7887264 | 0.67 | ALDH1A1 (0.59) | SMN1; SMN2HPGDKDM4EPTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280764-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001070675-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-09-27 | — | — | WO | disclosed |