Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7176716 | 0.83 | PKM (0.50) | ALDH1A1MAPTMEN1GAAKMT2A | |
| SCHEMBL7182956 | 0.80 | ALDH1A1 (0.38) | KDM4EALDH1A1GAAHSD17B10CYP2C19 | |
| SCHEMBL7191668 | 0.73 | PTGER4 (0.49) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL8793331 | 0.73 | CFTR (0.39) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7188766 | 0.72 | CFTR (0.47) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7449675 | 0.71 | CFTR (0.46) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL2235637 | 0.69 | CYP1A2 (0.55) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7359963 | 0.68 | ALDH1A1 (0.44) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7449680 | 0.67 | CFTR (0.46) | CFTRKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL7178329 | 0.66 | CFTR (0.42) | CFTRKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |