Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7191253 | 0.81 | MAPT (0.47) | ALDH1A1KDM4ETDP1L3MBTL1MAPT | |
| SCHEMBL7188766 | 0.79 | CFTR (0.47) | ALDH1A1KDM4EGAASSTR4L3MBTL1 | |
| SCHEMBL7183015 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4EGAAABCC9ABCC8 | |
| SCHEMBL7191231 | 0.75 | PTGER4 (0.48) | ALDH1A1KDM4EGAAMCHR1MAPT | |
| SCHEMBL7185647 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4EGAAABCC9ABCC8 | |
| SCHEMBL7194060 | 0.75 | KDM4E (0.54) | ALDH1A1KDM4EGAAPDK1PDK2 | |
| SCHEMBL7188673 | 0.73 | GAA (0.39) | ALDH1A1KDM4EGAAABCC9ABCC8 | |
| SCHEMBL7190795 | 0.73 | GAA (0.39) | ALDH1A1KDM4EGAAABCC9ABCC8 | |
| SCHEMBL7387168 | 0.72 | KDM4E (0.51) | ALDH1A1KDM4EGAAPDK1PDK2 | |
| SCHEMBL7182956 | 0.71 | ALDH1A1 (0.38) | ALDH1A1KDM4EGAAMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |