Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7190795 | 1.00 | GAA (0.39) | GAAKDM4EALDH1A1HCAR3MAP2K1 | |
| SCHEMBL7183015 | 0.85 | KDM4E (0.44) | GAAKDM4EALDH1A1HCAR3MAP2K1 | |
| SCHEMBL7185647 | 0.85 | KDM4E (0.44) | GAAKDM4EALDH1A1HCAR3MAP2K1 | |
| SCHEMBL7189685 | 0.83 | HCAR3 (0.53) | KDM4EALDH1A1HCAR3LMNATDP1 | |
| SCHEMBL7185695 | 0.83 | HCAR3 (0.53) | KDM4EALDH1A1HCAR3LMNATDP1 | |
| SCHEMBL7183531 | 0.73 | ALDH1A1 (0.41) | GAAKDM4EALDH1A1MAP2K1ABCC9 | |
| SCHEMBL7191231 | 0.73 | PTGER4 (0.48) | GAAKDM4EALDH1A1 | |
| SCHEMBL7387168 | 0.70 | KDM4E (0.51) | GAAKDM4EALDH1A1POLB | |
| SCHEMBL15595142 | 0.70 | LMNA (0.44) | GAAKDM4EALDH1A1MAP2K1GPR35 | |
| SCHEMBL2339309 | 0.70 | KDM4E (0.54) | GAAKDM4EALDH1A1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |