SCHEMBL7183658

SCHEMBL7183658

O=C(c1nccs1)C(Cc1cc[c]c(Br)c1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G4A P47712 1/20 0.38
CES1 P23141 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
PTPN1 P18031 5/20 0.36
PTPN2 P17706 1/20 0.36
MMP2 P08253 1/20 0.36
MMP3 P08254 1/20 0.36
MMP7 P09237 1/20 0.36
GRM5 P41594 1/20 0.36
CTSA P10619 1/20 0.35
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
ALDH1A1 P00352 1/20 0.34
EPHX1 P07099 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7166523 0.80 PTPN1 (0.53) CES1PTPN1PTPN2LMNARAB9A
SCHEMBL7594242 0.76 ESR1 (0.44) PTPN1PTPN2LMNAEPHX1CHRM1
SCHEMBL7629991 0.74 PTPN1 (0.43) PLA2G4ACES1CYP1A2CYP3A4CYP2D6
SCHEMBL7626425 0.73 PTPN1 (0.54) PLA2G4ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7594872 0.66 PTPN1 (0.37) PTPN1PTPN2
SCHEMBL7626428 0.66 PTPN1 (0.44) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL7373291 0.61 PLA2G4A (0.40) PLA2G4ACES1MMP2MMP3MMP7
SCHEMBL27628035 0.61 POLB (0.59) CES1CYP1A2CYP2C9CYP2C19PTPN1
SCHEMBL22344416 0.61 KDM4E (0.46) LMNATSHRALDH1A1
SCHEMBL31530570 0.61 LMNA (0.46) PLA2G4ACES1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003518130-A 2003-06-03 JP claimed
EP-1244678-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA INC. (CA) 2002-10-02 EP claimed
WO-2001046206-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA & CO. (CA) 2001-06-28 WO claimed
EP-1244678-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA INC. (CA) 2002-10-02 EP disclosed
WO-2001046206-A1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) MERCK FROSST CANADA & CO. (CA) 2001-06-28 WO disclosed