Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | MRE11 | P49959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7174193 | 0.77 | PTPN1 (0.41) | PTPN1PTPN2 | |
| SCHEMBL7618267 | 0.77 | PTPN1 (0.51) | PTPN1PTPN2 | |
| SCHEMBL7166523 | 0.76 | PTPN1 (0.53) | PTPN1PTPN2 | |
| SCHEMBL7183658 | 0.66 | PLA2G4A (0.38) | PTPN1PTPN2 | |
| SCHEMBL723821 | 0.63 | CES2 (0.42) | — | |
| SCHEMBL7591773 | 0.62 | KDM4E (0.45) | — | |
| SCHEMBL22344416 | 0.58 | KDM4E (0.46) | — | |
| SCHEMBL2922282 | 0.58 | MITF (0.59) | PTPN1 | |
| SCHEMBL27608960 | 0.58 | SLC7A5 (0.61) | PTPN1PTPN2 | |
| SCHEMBL3393204 | 0.57 | L3MBTL1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244678-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) | MERCK FROSST CANADA INC. (CA) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001046206-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) | MERCK FROSST CANADA & CO. (CA) | 2001-06-28 | — | — | WO | disclosed |