Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 12/20 | 0.56 |
| ▸ | KYNU | Q16719 | 2/20 | 0.54 |
| ▸ | MMP1 | P03956 | 5/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.52 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | TARS1 | P26639 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183670 | 1.00 | MMP13 (0.56) | MMP13KYNUMMP1MMP2SOS1 | |
| SCHEMBL27767605 | 0.85 | KYNU (0.65) | MMP13KYNU | |
| SCHEMBL9064967 | 0.85 | KYNU (0.65) | MMP13KYNU | |
| Hydrochloric Acid SCHEMBL7301537 | 0.85 | MMP13 (0.67) | MMP13MMP1MMP2MMP3MMP8 | |
| Hydrochloric Acid SCHEMBL7301531 | 0.85 | MMP13 (0.67) | MMP13MMP1MMP2MMP3MMP8 | |
| Hydrochloric Acid SCHEMBL7207769 | 0.82 | HTT (0.55) | MMP13KYNUMMP1 | |
| SCHEMBL7308976 | 0.82 | MMP13 (0.58) | MMP13MMP1MMP2TARS1 | |
| SCHEMBL7308959 | 0.82 | MMP13 (0.58) | MMP13MMP1MMP2TARS1 | |
| SCHEMBL7870745 | 0.79 | KYNU (0.57) | MMP13KYNUMMP1MMP2MMP3 | |
| SCHEMBL7178204 | 0.79 | MMP13 (0.75) | MMP13KYNUMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583299-B1 | Matrix metalloprotease inhibitors; nonsuppression of tumor necrosis factor production | G.D. SEARLE & CO. | 2003-06-24 | — | — | US | disclosed |
| EP-1178959-A1 | ALPHA-AMINO-BETA-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000071514-A1 | α-AMINO-β-SULFONYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. (US) | 2000-11-30 | — | — | WO | disclosed |