Sugi Predict

Sugi Predict / Compounds / SCHEMBL7183829

SCHEMBL7183829

SCHEMBL7183829

Cc1cccc(C)c1C(=O)[PH](=O)c1c(C)cc(C(=O)c2ccccc2)c(C)c1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.38
▸ MAPK14 Q16539 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ MYC P01106 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.36
▸ HPGD P15428 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.35
▸ AKR1C3 P42330 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ KCNK3 O14649 1/20 0.35
▸ KCNK9 Q9NPC2 1/20 0.35
▸ CYP2C8 P10632 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7184787 0.92 RORC (0.38) POLBMAPK14L3MBTL1MYCALDH1A1
SCHEMBL7174636 0.91 NPSR1 (0.37) POLBMAPK14ALDH1A1HPGDNPSR1
SCHEMBL7181156 0.89 MAPT (0.39) POLBATMTDP1L3MBTL1MYC
SCHEMBL7182423 0.88 ALDH1A1 (0.37) POLBMAPK14TDP1L3MBTL1ALDH1A1
SCHEMBL7181622 0.87 NPSR1 (0.34) POLBMAPK14MYCALDH1A1HPGD
SCHEMBL7188418 0.87 MAPT (0.43) L3MBTL1ALDH1A1HPGDNPSR1LMNA
SCHEMBL7183567 0.86 ATM (0.39) MAPK14ATMTDP1L3MBTL1ALDH1A1
SCHEMBL7180485 0.86 NR1H2 (0.40) POLBMAPK14ALDH1A1HPGDNPSR1
SCHEMBL7178033 0.85 HTT (0.40) POLBMAPK14ATMTDP1L3MBTL1
SCHEMBL7177292 0.82 HTT (0.38) POLBMAPK14ATMTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 POLB 2322/4885MAPK14 952/4885ATM 2823/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 POLB 2993/4885MAPK14 1415/4885ATM 2935/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.