Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178285 | 1.00 | HCAR3 (0.55) | HCAR3POLBMAPTKAT2BNPC1 | |
| SCHEMBL7182851 | 0.92 | KAT2B (0.54) | HCAR3POLBMAPTKAT2BNPC1 | |
| SCHEMBL7189685 | 0.85 | HCAR3 (0.53) | HCAR3POLBMAPTKAT2BALDH1A1 | |
| SCHEMBL7185695 | 0.85 | HCAR3 (0.53) | HCAR3POLBMAPTKAT2BALDH1A1 | |
| SCHEMBL7182036 | 0.85 | KAT2B (0.52) | HCAR3MAPTKAT2BALDH1A1KMT2A | |
| SCHEMBL7190773 | 0.85 | KAT2B (0.52) | HCAR3MAPTKAT2BALDH1A1KMT2A | |
| SCHEMBL10890786 | 0.84 | HCAR3 (0.60) | HCAR3POLBMAPTNPC1ALDH1A1 | |
| SCHEMBL10804673 | 0.81 | HCAR3 (0.59) | HCAR3POLBMAPTNPC1ALDH1A1 | |
| SCHEMBL5652691 | 0.78 | PKM (0.39) | MAPTKMT2APKM | |
| SCHEMBL5789390 | 0.78 | MAPT (0.60) | HCAR3POLBMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |