Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185695 | 1.00 | HCAR3 (0.53) | HCAR3MAPTKMT2AKAT2BRAB9A | |
| SCHEMBL7190961 | 0.88 | HCAR3 (0.53) | HCAR3MAPTKMT2AKAT2BRAB9A | |
| SCHEMBL7184178 | 0.88 | HCAR3 (0.53) | HCAR3MAPTKMT2AKAT2BRAB9A | |
| SCHEMBL7178285 | 0.85 | HCAR3 (0.55) | HCAR3MAPTKMT2AKAT2BRAB9A | |
| SCHEMBL7183876 | 0.85 | HCAR3 (0.55) | HCAR3MAPTKMT2AKAT2BRAB9A | |
| SCHEMBL7188673 | 0.83 | GAA (0.39) | HCAR3LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7190795 | 0.83 | GAA (0.39) | HCAR3LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7182851 | 0.80 | KAT2B (0.54) | HCAR3MAPTKMT2AKAT2BRAB9A | |
| SCHEMBL7191253 | 0.76 | MAPT (0.47) | MAPTKMT2AKAT2BRAB9ALMNA | |
| SCHEMBL7179435 | 0.76 | KAT2B (0.64) | HCAR3MAPTKMT2AKAT2BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |