Sugi Predict

Sugi Predict / Compounds / SCHEMBL7184537

SCHEMBL7184537

SCHEMBL7184537

Cc1cc(C)c(C(=O)[P](=O)c2ccccc2C(=O)c2c(Cl)ccc(Cl)c2Cl)c(C)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.43
▸ KMT2A Q03164 4/20 0.43
▸ LMNA P02545 4/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ MAPK13 O15264 2/20 0.33
▸ MAPK12 P53778 2/20 0.33
▸ MAPK11 Q15759 2/20 0.33
▸ MAPK14 Q16539 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ RORC P51449 3/20 0.32
▸ AKR1B10 O60218 1/20 0.32
▸ ABCB11 O95342 1/20 0.32
▸ TTR P02766 1/20 0.32
▸ ADORA3 P0DMS8 1/20 0.32
▸ CHRM1 P11229 1/20 0.32
▸ FABP2 P12104 1/20 0.32
▸ RXRA P19793 1/20 0.32
▸ TBXA2R P21731 1/20 0.32
▸ NR4A1 P22736 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7174841 0.91 MEN1 (0.43) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7184123 0.90 RORC (0.38) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7181110 0.90 MEN1 (0.47) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7186638 0.89 MEN1 (0.42) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7177503 0.88 LMNA (0.36) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7190480 0.88 MEN1 (0.47) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7188758 0.86 MEN1 (0.43) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7189834 0.84 TSHR (0.40) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7180500 0.83 KMT2A (0.39) MEN1KMT2ALMNAALDH1A1GAA
SCHEMBL7183573 0.83 KMT2A (0.39) MEN1KMT2ALMNAALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MEN1 2312/4885KMT2A 1586/4885LMNA 3241/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MEN1 2263/4885KMT2A 956/4885LMNA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.