Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189834

SCHEMBL7189834

SCHEMBL7189834

O=C(c1ccccc1[P](=O)C(=O)c1c(Cl)cccc1Cl)c1c(Cl)ccc(Cl)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.40
▸ P2RX7 Q99572 1/20 0.36
▸ ALDH1A1 P00352 4/20 0.36
▸ LMNA P02545 2/20 0.36
▸ GAA P10253 2/20 0.36
▸ CES2 O00748 1/20 0.36
▸ CES1 P23141 1/20 0.36
▸ PBRM1 Q86U86 1/20 0.35
▸ CNR2 P34972 2/20 0.34
▸ ERCC5 P28715 1/20 0.34
▸ FEN1 P39748 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ RORC P51449 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ KMT2A Q03164 2/20 0.33
▸ POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180955 0.90 RECQL (0.36) TSHRALDH1A1LMNAGAACES2
SCHEMBL7179370 0.90 TSHR (0.38) TSHRP2RX7ALDH1A1LMNAGAA
SCHEMBL7184123 0.89 RORC (0.38) TSHRP2RX7ALDH1A1LMNAGAA
SCHEMBL7186460 0.87 RORC (0.41) LMNAGAARORCCYP3A4CYP2C9
SCHEMBL7174638 0.86 HPGD (0.38) ALDH1A1LMNAGAACES2CES1
SCHEMBL7183647 0.84 RORC (0.39) ALDH1A1LMNAGAACES2CES1
SCHEMBL7188910 0.84 ALDH1A1 (0.44) ALDH1A1LMNAGAACES2CES1
SCHEMBL7179797 0.84 RORC (0.42) ALDH1A1LMNAGAACNR2RORC
SCHEMBL7184537 0.84 MEN1 (0.43) ALDH1A1LMNAGAACNR2RORC
SCHEMBL7177503 0.82 LMNA (0.36) ALDH1A1LMNAGAACNR2RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TSHR 984/4885P2RX7 4680/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TSHR 1273/4885P2RX7 4753/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.