Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | SDHB | P21912 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500317 | 0.79 | SCD (0.54) | NPBWR1SCDSMN1; SMN2ALDH1A1MAPK13 | |
| SCHEMBL9006008 | 0.74 | HPGD (0.50) | HPGDNPBWR1POLBRAB9AALDH1A1 | |
| SCHEMBL9275955 | 0.73 | ESR1 (0.50) | HPGDPOLBMEN1S1PR4LMNA | |
| SCHEMBL655574 | 0.72 | HPGD (0.49) | HPGDNPBWR1POLBMEN1MAPK1 | |
| SCHEMBL8677012 | 0.71 | KMT2A (0.66) | HPGDNPBWR1POLBMEN1HTT | |
| SCHEMBL25010255 | 0.71 | LMNA (0.48) | HPGDNPBWR1SCDMEN1LMNA | |
| SCHEMBL649956 | 0.69 | HPGD (0.45) | HPGDNPBWR1MAPK1RAB9APIN1 | |
| SCHEMBL8678923 | 0.68 | KDM4E (0.48) | HPGDPOLBMEN1MAPK1HTT | |
| SCHEMBL29286633 | 0.67 | PIN1 (0.53) | POLBRAB9AKMT2APIN1MAPK13 | |
| SCHEMBL8677247 | 0.67 | SMN1; SMN2 (0.62) | HPGDPOLBLMNAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1365753-A2 | UROGUANYLIN AND CYCLOOXYGENASE-2 INHIBITOR COMBINATIONS FOR INHIBITION OF INTESTINAL CANCER | Pharmacia Corporation (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002062369-A2 | UROGUANYLIN AND CYCLOOXYGENASE-2 INHIBITOR COMBINATIONS FOR INHIBITION OF INTESTINAL CANCER | PHARMACIA CORPORATION (US) | 2002-08-15 | — | — | WO | disclosed |
| EP-0979077-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. Searle & Co. (US) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998047509-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1998-10-29 | — | — | WO | disclosed |