Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.48 |
| ▸ | YEATS4 | O95619 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | PLD2 | O14939 | 8/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.44 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.44 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7184792 | 1.00 | ALDH1A1 (0.54) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| SCHEMBL18477021 | 0.95 | ALDH1A1 (0.58) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| SCHEMBL5837066 | 0.90 | ALDH1A1 (0.62) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| SCHEMBL13153966 | 0.88 | ALDH1A1 (0.57) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| Hydrochloric Acid SCHEMBL29848399 | 0.87 | ALDH1A1 (0.56) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| SCHEMBL7190435 | 0.86 | USP2 (0.55) | ALDH1A1USP2LMNAHSD11B1YEATS4 | |
| SCHEMBL7190427 | 0.86 | USP2 (0.55) | ALDH1A1USP2LMNAHSD11B1YEATS4 | |
| SCHEMBL13153970 | 0.85 | HSD11B1 (0.55) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| SCHEMBL20529154 | 0.85 | ALDH1A1 (0.52) | ALDH1A1USP2LMNAMAPK1HSD11B1 | |
| SCHEMBL13899733 | 0.84 | ALDH1A1 (0.52) | ALDH1A1USP2LMNAMAPK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |