Sugi Predict

Sugi Predict / Compounds / SCHEMBL7184898

SCHEMBL7184898

SCHEMBL7184898

COc1c(C)c(C(=O)c2ccccc2)c(C)c(OC)c1[PH](=O)C(=O)c1c(C)cc(C(C)(C)C)cc1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TNFRSF1A P19438 1/20 0.36
▸ HPGD P15428 3/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP2D6 P10635 2/20 0.35
▸ CYP2C19 P33261 2/20 0.35
▸ LMNA P02545 4/20 0.34
▸ ATM Q13315 1/20 0.34
▸ MAPT P10636 3/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ TDP1 Q9NUW8 2/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ RXRA P19793 1/20 0.33
▸ RXRB P28702 1/20 0.33
▸ HTT P42858 2/20 0.33
▸ PGR P06401 1/20 0.33
▸ SLC6A2 P23975 1/20 0.33
▸ PDE4A P27815 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ HRH1 P35367 1/20 0.33
▸ SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182193 0.89 HPGD (0.37) HPGDCYP1A2CYP2D6CYP2C19LMNA
SCHEMBL7181244 0.89 TNFRSF1A (0.35) TNFRSF1AHPGDCYP1A2CYP2D6CYP2C19
SCHEMBL7189016 0.87 ALDH1A1 (0.38) HPGDCYP1A2CYP2D6CYP2C19LMNA
SCHEMBL7190429 0.87 LMNA (0.38) LMNAATMMAPTALDH1A1TDP1
SCHEMBL7181463 0.86 HPGD (0.36) HPGDCYP1A2CYP2D6CYP2C19LMNA
SCHEMBL7178026 0.85 ATM (0.37) TNFRSF1AHPGDCYP1A2CYP2D6CYP2C19
SCHEMBL7175881 0.84 LMNA (0.36) LMNAATMMAPTALDH1A1TDP1
SCHEMBL7190266 0.84 MAPT (0.39) HPGDCYP1A2CYP2D6CYP2C19LMNA
SCHEMBL7187402 0.83 LMNA (0.37) LMNAATMMAPTALDH1A1TDP1
SCHEMBL7178025 0.82 KMT2A (0.34) TNFRSF1AHPGDCYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TNFRSF1A 4237/4885HPGD 3983/4885CYP1A2 1595/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TNFRSF1A 4442/4885HPGD 4041/4885CYP1A2 2020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.