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SCHEMBL7181244

SCHEMBL7181244

COc1c(Cl)c(C(=O)c2ccccc2)c(Cl)c(OC)c1[PH](=O)C(=O)c1c(C)cc(C(C)(C)C)cc1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TNFRSF1A P19438 1/20 0.35
▸ LMNA P02545 3/20 0.33
▸ TAS1R3 Q7RTX0 1/20 0.33
▸ TAS1R1 Q7RTX1 1/20 0.33
▸ TAS1R2 Q8TE23 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ MAPT P10636 2/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ CCR9 P51686 1/20 0.32
▸ TUBB4A P04350 1/20 0.32
▸ TUBB P07437 1/20 0.32
▸ TUBA3C P0DPH7 1/20 0.32
▸ TUBA1B P68363 1/20 0.32
▸ TUBA4A P68366 1/20 0.32
▸ TUBB4B P68371 1/20 0.32
▸ TUBB3 Q13509 1/20 0.32
▸ TUBB2A Q13885 1/20 0.32
▸ TUBB8 Q3ZCM7 1/20 0.32
▸ TUBA3E Q6PEY2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189208 0.90 TAS1R3 (0.35) LMNATAS1R3TAS1R1TAS1R2ATM
SCHEMBL7184898 0.89 TNFRSF1A (0.36) TNFRSF1ALMNAATMMAPTTDP1
SCHEMBL7178025 0.89 KMT2A (0.34) TNFRSF1ALMNATAS1R3TAS1R1TAS1R2
SCHEMBL7182760 0.87 TAS1R3 (0.36) LMNATAS1R3TAS1R1TAS1R2ATM
SCHEMBL7182634 0.87 LMNA (0.36) LMNAMAPTTDP1L3MBTL1CNR2
SCHEMBL7177974 0.85 TAS1R3 (0.34) LMNATAS1R3TAS1R1TAS1R2ATM
SCHEMBL7178026 0.83 ATM (0.37) TNFRSF1ALMNAATMMAPTTUBB4A
SCHEMBL7189282 0.82 LMNA (0.34) LMNAATMMAPTTDP1L3MBTL1
SCHEMBL7189330 0.82 ALDH1A1 (0.38) LMNATAS1R3TAS1R1TAS1R2MAPT
SCHEMBL7190266 0.82 MAPT (0.39) LMNAATMMAPTTUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TNFRSF1A 4237/4885LMNA 3241/4885TAS1R3 2990/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TNFRSF1A 4442/4885LMNA 3247/4885TAS1R3 3176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.