Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.38 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185544 | 1.00 | HSP90AA1 (0.43) | HSP90AA1ADORA1ALOX15KDM4EGAA | |
| SCHEMBL2731890 | 0.92 | KDM4E (0.46) | ALOX15KDM4EGAAMAPTTP53 | |
| SCHEMBL29860401 | 0.92 | KDM4E (0.46) | ALOX15KDM4EGAAMAPTTP53 | |
| SCHEMBL3792292 | 0.83 | KDM4E (0.59) | ALOX15KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL7794045 | 0.83 | RAB9A (0.48) | HSP90AA1ADORA1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL20096321 | 0.81 | AAK1 (0.46) | HSP90AA1ALOX15KDM4EGAAMAPT | |
| SCHEMBL13500619 | 0.81 | HSP90AA1 (0.43) | HSP90AA1ALOX15KDM4EGAAMAPT | |
| SCHEMBL22725031 | 0.81 | IKBKB (0.42) | ALOX15KDM4EGAAMAPTTP53 | |
| SCHEMBL21293969 | 0.81 | AAK1 (0.46) | HSP90AA1ALOX15KDM4EGAAMAPT | |
| SCHEMBL17675692 | 0.81 | MAPK1 (0.45) | ALOX15KDM4EGAAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |