Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183929 | 0.84 | ALDH1A1 (0.42) | ALDH1A1GLAIRAK4VCAM1JAK2 | |
| SCHEMBL16722232 | 0.81 | ALDH1A1 (0.47) | ALDH1A1GLAMAPTLMNACYP1A2 | |
| SCHEMBL16722235 | 0.81 | ALDH1A1 (0.47) | ALDH1A1GLAMAPTLMNACYP1A2 | |
| SCHEMBL25887391 | 0.78 | VCAM1 (0.47) | ALDH1A1VCAM1JAK2JAK3MAPT | |
| SCHEMBL30989701 | 0.78 | VCAM1 (0.47) | ALDH1A1VCAM1JAK2JAK3MAPT | |
| SCHEMBL7190772 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNAPKMCYP1A2 | |
| SCHEMBL7190773 | 0.77 | KAT2B (0.52) | ALDH1A1VCAM1MAPTLMNAPKM | |
| SCHEMBL7182036 | 0.77 | KAT2B (0.52) | ALDH1A1VCAM1MAPTLMNAPKM | |
| SCHEMBL26914256 | 0.76 | GLA (0.41) | ALDH1A1GLAVCAM1JAK2JAK3 | |
| SCHEMBL26914255 | 0.76 | GLA (0.41) | ALDH1A1GLAVCAM1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |