Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775274 | 0.82 | SMN1; SMN2 (0.40) | CES2CES1HPGDLMNAALDH1A1 | |
| SCHEMBL5769961 | 0.81 | MEN1 (0.46) | CES2CES1HPGDLMNAMAPT | |
| SCHEMBL26701682 | 0.76 | KDM4E (0.58) | CES2CES1HPGDLMNAALDH1A1 | |
| SCHEMBL1942112 | 0.73 | ALOX5 (0.51) | HPGDMAPTALDH1A1TSHRRAB9A | |
| SCHEMBL5776748 | 0.73 | KMT2A (0.50) | HPGDLMNAMAPTALDH1A1TSHR | |
| SCHEMBL7182897 | 0.73 | HPGD (0.50) | HPGDMAPTALDH1A1TSHRMLYCD | |
| SCHEMBL5778017 | 0.73 | HPGD (0.47) | CES2HPGDLMNATSHRMLYCD | |
| SCHEMBL5773765 | 0.73 | LMNA (0.51) | HPGDLMNAMAPTALDH1A1RAB9A | |
| SCHEMBL5773245 | 0.72 | SMN1; SMN2 (0.58) | CES2CES1HPGDLMNAMAPT | |
| SCHEMBL1934947 | 0.68 | HPGD (0.55) | HPGDALDH1A1KMT2AHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |