Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574011 | 0.79 | SMN1; SMN2 (0.50) | KMT2AMAPTNPSR1POLBSMN1; SMN2 | |
| SCHEMBL5775274 | 0.75 | SMN1; SMN2 (0.40) | KMT2ASMN1; SMN2HPGDLMNAALDH1A1 | |
| SCHEMBL7182897 | 0.75 | HPGD (0.50) | KMT2AMAPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL7185944 | 0.73 | CES2 (0.40) | KMT2AMAPTNPSR1HPGDRAB9A | |
| SCHEMBL29944043 | 0.73 | HSD11B1 (0.66) | KMT2AMAPTNPSR1POLBSPR | |
| SCHEMBL3456204 | 0.73 | HSD11B1 (0.66) | KMT2AMAPTNPSR1POLBSPR | |
| SCHEMBL5778017 | 0.71 | HPGD (0.47) | KMT2APOLBSMN1; SMN2HPGDLMNA | |
| SCHEMBL5769961 | 0.71 | MEN1 (0.46) | KMT2AMAPTNPSR1HPGDRAB9A | |
| SCHEMBL1934947 | 0.70 | HPGD (0.55) | KMT2AHPGDNPC1ALDH1A1 | |
| SCHEMBL5772555 | 0.68 | ALDH1A1 (0.70) | KMT2AMAPTPOLBSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |