SCHEMBL7186116

SCHEMBL7186116

Cc1c(CC(=O)O)ccc(Cl)c1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCL8 P10145 5/20 0.47
CLIC1 O00299 1/20 0.47
CLCN2 P51788 1/20 0.47
AKR1B1 P15121 2/20 0.42
SRC P12931 1/20 0.42
PTGS2 P35354 5/20 0.41
PTGS1 P23219 2/20 0.40
CAMK2A Q9UQM7 3/20 0.40
CYP2C9 P11712 1/20 0.40
AKR1B10 O60218 1/20 0.39
UGT1A9 O60656 1/20 0.39
TRPA1 O75762 1/20 0.39
ABCB11 O95342 1/20 0.39
MT-CO2 P00403 1/20 0.39
TTR P02766 1/20 0.39
ALB P02768 1/20 0.39
UGT1A6 P19224 1/20 0.39
UGT1A1 P22309 1/20 0.39
CXCR1 P25024 1/20 0.39
ADRA1A P35348 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697243 0.86 CXCL8 (0.44) CXCL8CLIC1CLCN2AKR1B1SRC
SCHEMBL13922724 0.85 GSK3B (0.40) CXCL8CLIC1CLCN2
SCHEMBL4900831 0.84 CXCL8 (0.50) CXCL8CLIC1CLCN2AKR1B1PTGS2
Hydrochloric Acid SCHEMBL11408340 0.82 CXCL8 (0.49) CXCL8CLIC1CLCN2AKR1B1PTGS2
SCHEMBL9926557 0.81 CXCL8 (0.41) CXCL8CLIC1CLCN2AKR1B1SRC
SCHEMBL11741944 0.81 SRC (0.52) AKR1B1SRCPTGS2PTGS1CAMK2A
SCHEMBL9477716 0.78 AKR1B1 (0.45) CXCL8CLIC1CLCN2AKR1B1PTGS2
SCHEMBL7192003 0.78 AKR1B1 (0.44) CXCL8CLIC1CLCN2AKR1B1SRC
SCHEMBL30427864 0.78 RXRA (0.44) CXCL8CLIC1CLCN2SRCPTGS2
SCHEMBL29009948 0.78 RXRA (0.44) CXCL8CLIC1CLCN2SRCPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030114596-A1 Thermoplastic elastomer composition and ethylene-alpha-olefin copolymer SUMITOMO CHEMICAL COMPANY, LIMITED 2003-06-19 US disclosed
US-6541592-B1 An ethylene- alpha -olefin copolymer (alpha -olefin having 3 to 8 carbon atoms and content from 20-33.7wt %), Moony viscosity ML1+4100 degree C. of from 20-60, tensile stress M100 of 2.5 Mpa; excellent flexability, and processability SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-04-01 US disclosed
EP-0660024-B1 Resin-coated pipe SUMITOMO CHEMICAL CO (JP) 1997-10-22 EP disclosed
US-5571585-A HAVING EXCELLENT PROCESSABILITY, MECHANICAL STRENGTH, NORMAL AND LOW TEMPERATURE IMPACT RESISTANCE, HEAT RESISTANCE, CHIPPING RESISTANCE AND COATING SURFACE APPEEARANCE SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-11-05 US disclosed
EP-0660024-A1 Resin-coated pipe SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-06-28 EP disclosed