SCHEMBL7192003

SCHEMBL7192003

CCc1c(CC(=O)O)ccc(Cl)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 2/20 0.44
CXCL8 P10145 5/20 0.41
CLCN2 P51788 2/20 0.41
CLIC1 O00299 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.39
ABCB1 P08183 1/20 0.38
CAMK2A Q9UQM7 3/20 0.38
CYP2C9 P11712 1/20 0.38
PTGS2 P35354 4/20 0.37
AKR1B10 O60218 1/20 0.37
UGT1A9 O60656 1/20 0.37
TRPA1 O75762 1/20 0.37
ABCB11 O95342 1/20 0.37
MT-CO2 P00403 1/20 0.37
TTR P02766 1/20 0.37
ALB P02768 1/20 0.37
UGT1A6 P19224 1/20 0.37
UGT1A1 P22309 1/20 0.37
PTGS1 P23219 1/20 0.37
CXCR1 P25024 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2662577 0.82 CTRC (0.39) CLCN2
SCHEMBL4900831 0.81 CXCL8 (0.50) AKR1B1CXCL8CLCN2CLIC1CAMK2A
Hydrochloric Acid SCHEMBL11408340 0.79 CXCL8 (0.49) AKR1B1CXCL8CLCN2CLIC1CAMK2A
SCHEMBL30938849 0.79 AKR1B1 (0.63) AKR1B1CXCL8ABCB1CAMK2APTGS2
SCHEMBL6607590 0.78 AKR1B1 (0.41) AKR1B1CXCL8CLCN2CLIC1PTGDR2
SCHEMBL7186116 0.78 CXCL8 (0.47) AKR1B1CXCL8CLCN2CLIC1CAMK2A
SCHEMBL55504 0.77 AKR1B1 (0.65) AKR1B1CXCL8CLCN2CLIC1CAMK2A
SCHEMBL29397431 0.77 AKR1B1 (0.65) AKR1B1CXCL8CLCN2CLIC1CAMK2A
SCHEMBL1701239 0.77 AKR1B1 (0.65) AKR1B1CXCL8CLCN2CLIC1CAMK2A
SCHEMBL9477716 0.76 AKR1B1 (0.45) AKR1B1CXCL8CLCN2CLIC1CAMK2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0546629-B1 Process for preparing elastomeric copolymers of ethylene with a high tensile strength of the crude product ENICHEM ELASTOMERS (IT) 1997-02-26 EP claimed
EP-0546629-A1 Process for preparing elastomeric copolymers of ethylene with a high tensile strength of the crude product ENICHEM ELASTOMERI S.r.l. (IT) 1993-06-16 EP claimed
US-20030114596-A1 Thermoplastic elastomer composition and ethylene-alpha-olefin copolymer SUMITOMO CHEMICAL COMPANY, LIMITED 2003-06-19 US disclosed
US-6541592-B1 An ethylene- alpha -olefin copolymer (alpha -olefin having 3 to 8 carbon atoms and content from 20-33.7wt %), Moony viscosity ML1+4100 degree C. of from 20-60, tensile stress M100 of 2.5 Mpa; excellent flexability, and processability SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-04-01 US disclosed
EP-0660024-B1 Resin-coated pipe SUMITOMO CHEMICAL CO (JP) 1997-10-22 EP disclosed
EP-0546629-B1 Process for preparing elastomeric copolymers of ethylene with a high tensile strength of the crude product ENICHEM ELASTOMERS (IT) 1997-02-26 EP disclosed
US-5571585-A HAVING EXCELLENT PROCESSABILITY, MECHANICAL STRENGTH, NORMAL AND LOW TEMPERATURE IMPACT RESISTANCE, HEAT RESISTANCE, CHIPPING RESISTANCE AND COATING SURFACE APPEEARANCE SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-11-05 US disclosed
EP-0660024-A1 Resin-coated pipe SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-06-28 EP disclosed
EP-0546629-A1 Process for preparing elastomeric copolymers of ethylene with a high tensile strength of the crude product ENICHEM ELASTOMERI S.r.l. (IT) 1993-06-16 EP disclosed