Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.43 |
| ▸ | STS | P08842 | 5/20 | 0.39 |
| ▸ | ESR1 | P03372 | 7/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | SHBG | P04278 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.37 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179669 | 0.87 | HSD17B1 (0.58) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7175364 | 0.87 | HSD17B1 (0.58) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7188971 | 0.86 | HSD17B1 (0.42) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7188895 | 0.85 | HSD17B1 (0.44) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL8710195 | 0.83 | STS (0.47) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7175660 | 0.81 | HSD17B1 (0.48) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7175664 | 0.81 | HSD17B1 (0.48) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7182171 | 0.79 | HSD17B1 (0.42) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL7187506 | 0.79 | HSD17B1 (0.42) | HSD17B1STSESR1ESR2LMNA | |
| SCHEMBL6266816 | 0.78 | SHBG (0.43) | HSD17B1STSESR1ESR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | claimed |
| US-6583130-B1 | Substituted with acyl, oxycarbonyl, aminocarbonyl, sulfonyl, or aminosulfonyl; inhibit steroid sulfatase, do not exhibit any estrogenic effect and will not yield any estrogenic products on hydrolysis; treatment of estrogen-dependent tumors | SCHERING AG (DE) | 2003-06-24 | — | — | US | disclosed |