Sugi Predict

Sugi Predict / Compounds / SCHEMBL7186789

SCHEMBL7186789

SCHEMBL7186789

Cc1cc(C)c([PH](=O)C(=O)c2c(C(F)(F)F)cccc2C(F)(F)F)c(C)c1C(=O)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 1/20 0.37
▸ NR1H3 Q13133 1/20 0.37
▸ ALDH1A1 P00352 5/20 0.36
▸ NPSR1 Q6W5P4 3/20 0.36
▸ MAPT P10636 2/20 0.36
▸ ALOX12 P18054 2/20 0.36
▸ TAS2R14 Q9NYV8 1/20 0.36
▸ KCNK3 O14649 2/20 0.35
▸ KCNK9 Q9NPC2 2/20 0.35
▸ HDAC1 Q13547 1/20 0.35
▸ HDAC8 Q9BY41 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ CYP1A2 P05177 3/20 0.34
▸ POLB P06746 2/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ CYP2C9 P11712 2/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180485 0.88 NR1H2 (0.40) NR1H2NR1H3ALDH1A1NPSR1MAPT
SCHEMBL7187544 0.85 NR1H2 (0.38) NR1H2NR1H3ALDH1A1NPSR1MAPT
SCHEMBL7180924 0.85 NR1H2 (0.39) NR1H2NR1H3ALDH1A1NPSR1MAPT
SCHEMBL7183567 0.85 ATM (0.39) ALDH1A1MAPTKCNK3KCNK9CYP1A2
SCHEMBL7175295 0.85 NR1H2 (0.41) NR1H2NR1H3ALDH1A1TAS2R14KCNK3
SCHEMBL7180520 0.82 ALDH1A1 (0.36) ALDH1A1MAPTCYP1A2MEN1CYP2C9
SCHEMBL7187402 0.81 LMNA (0.37) ALDH1A1NPSR1MAPTKCNK9MEN1
SCHEMBL7190475 0.81 ALDH1A1 (0.40) ALDH1A1MAPTKCNK3KCNK9CYP2C9
SCHEMBL7735674 0.80 MAOB (0.36) NR1H2NR1H3ALDH1A1NPSR1MAPT
SCHEMBL7188495 0.80 CA12 (0.41) ALDH1A1MAPTCYP1A2MEN1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 NR1H2 63/4885NR1H3 41/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 NR1H2 95/4885NR1H3 64/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.