Sugi Predict

Sugi Predict / Compounds / SCHEMBL7186983

SCHEMBL7186983

SCHEMBL7186983

Cc1cc(C)c(C)c(C(=O)c2ccccc2P)c1C.[LiH]

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.37
▸ HSD17B10 Q99714 3/20 0.37
▸ HPGD P15428 3/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ CRHBP P24387 1/20 0.37
▸ CRHR2 Q13324 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ LMNA P02545 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ GFER P55789 1/20 0.34
▸ MAPK13 O15264 3/20 0.33
▸ MAPK12 P53778 3/20 0.33
▸ MAPK11 Q15759 3/20 0.33
▸ MAPK14 Q16539 3/20 0.33
▸ BCL2L1 Q07817 1/20 0.33
▸ POLB P06746 2/20 0.33
▸ CDC25A P30304 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175276 0.90 ALDH1A1 (0.35) ALDH1A1HSD17B10HPGDKMT2AKDM4E
SCHEMBL7180022 0.87 GFER (0.43) ALDH1A1KMT2ACYP3A4CYP2C9LMNA
SCHEMBL7183110 0.86 ALDH1A1 (0.36) ALDH1A1HSD17B10HPGDKMT2AKDM4E
SCHEMBL7177456 0.83 KMT2A (0.41) ALDH1A1HPGDKMT2AMEN1LMNA
SCHEMBL7183628 0.82 CYP3A4 (0.42) ALDH1A1HSD17B10HPGDKMT2AKDM4E
SCHEMBL98046 0.81 KMT2A (0.42) ALDH1A1HPGDKMT2AMEN1LMNA
SCHEMBL12002964 0.79 KMT2A (0.41) ALDH1A1HPGDKMT2AMEN1LMNA
SCHEMBL8069534 0.77 CES2 (0.48) ALDH1A1HSD17B10HPGDKMT2AKDM4E
SCHEMBL4583582 0.75 CYP3A4 (0.39) ALDH1A1HSD17B10HPGDKMT2AMEN1
SCHEMBL13836777 0.75 ALDH1A1 (0.39) ALDH1A1HSD17B10HPGDKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885HSD17B10 56/4885HPGD 3983/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885HSD17B10 42/4885HPGD 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.