Gpi-1046

Gpi-1046

SCHEMBL7187

CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCc1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 18/20 1.00
MTOR P42345 1/20 1.00
FKBP4 Q02790 1/20 1.00
FKBP5 Q13451 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gpi-1046 SCHEMBL4766380 1.00 FKBP1A (1.00) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL2191097 0.99 FKBP1A (0.98) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL7324245 0.99 FKBP1A (0.98) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL2542494 0.98 FKBP1A (0.96) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL182073 0.97 FKBP1A (0.95) FKBP1AMTORFKBP4FKBP5
SCHEMBL5965941 0.97 FKBP1A (1.00) FKBP1AMTORFKBP4FKBP5
SCHEMBL7246114 0.94 FKBP1A (0.90) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL2537059 0.94 FKBP1A (0.89) FKBP1AMTORFKBP4FKBP5
Gpi-1046 SCHEMBL19386253 0.93 FKBP1A (0.87) FKBP1AMTORFKBP4FKBP5
SCHEMBL7767569 0.92 FKBP1A (1.00) FKBP1AMTORFKBP4FKBP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 50543 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4745155-A1 POWDER CONTAINING PARTICLES OF GELATIN DERIVATIVE AND APPLICATION OF SAME IN MEDICAL TREATMENT National Institute for Materials Science (JP) 2026-05-20 EP claimed
EP-4741421-A1 FAB-ARM EXCHANGE-PREVENTING FC VARIANTS FROM WHICH EFFECTOR FUNCTIONS ARE REMOVED Korea University Research and Business Foundation (KR) 2026-05-13 EP claimed
US-12622973-B2 Rejuvenation of CAR T cell PURDUE RESEARCH FOUNDATION (US) 2026-05-12 US claimed
EP-4118431-B1 INHIBITION OF FKBP1A FOR THE TREATMENT OF TRIPLE-NEGATIVE MAMMARY CARCINOMA HEINRICH HEINE UNIV DUESSELDORF (DE) 2026-05-06 EP claimed
US-20260117199-A1 ARTIFICIAL COMPLEX FOR TETHERING CHROMATIDS OR CHROMOSOMES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2026-04-30 US claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-12599701-B2 Drug delivery system and methods of using the same AXOGEN CORPORATION (US) 2026-04-14 US claimed
EP-4282978-B1 A UNIVERSAL PLATFORM FOR CAR THERAPY TARGETING A NOVEL ANTIGENIC SIGNATURE OF CANCER GAVISH GALILEE BIO APPL LTD (IL) 2026-04-01 EP claimed
EP-4713473-A1 SYSTEM AND METHOD FOR CHECKING THE ABILITY OF A PROTEIN OF INTEREST TO ACT AS A SUBSTRATE FOR AN ENZYME Julius-Maximilians-Universität Würzburg, in Vertretung des Freistaates Bayern (DE) 2026-03-25 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
WO-1993003364-A1 DETECTION OF IMMUNOSUPPRESSANTS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1993-02-18 WO claimed
US-5164495-A ESTERIFICATION, TRIETHYLAMINE ABBOTT LABORATORIES (US) 1992-11-17 US claimed
WO-1992019745-A1 RFKBP: A NOVEL PROLYL ISOMERASE AND RAPAMYCIN/FK506 BINDING PROTEIN VERTEX PHARMACEUTICALS INCORPORATED (US) 1992-11-12 WO claimed
WO-1992008474-A2 TREATMENT OF LUNG DISEASES THE NATIONAL HEART & LUNG INSTITUTE (GB) 1992-05-29 WO claimed
WO-1992004055-A1 IMMUNOSUPPRESSANT COMPOSITION THE AUSTRALIAN NATIONAL UNIVERSITY (AU) 1992-03-19 WO claimed
WO-1992000739-A1 3-PHENYL-5,6-DIHYDROBENZ[C]ACRIDINE-7-CARBOXYLIC ACIDS AND RELATED COMPOUNDS AS IMMUNOSUPPRESIVE AGENTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-23 WO claimed
WO-1991019498-A1 TREATMENT OF ORGAN TRANSPLANTATION REJECTION THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1991-12-26 WO claimed
CN-1056240-A INHIBITION NF ALLOGRAFT AND CONCORDANT XENOGRAFT REJECTION IMUTRAN LTD (GB) 1991-11-20 CN claimed
WO-1991004321-A1 RECEPTOR FOR FK-506 PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 1991-04-04 WO claimed
EP-0401747-A2 Use of rapamycin and derivatives and prodrugs thereof in the manufacture of a medicament for inhibiting transplant rejection in mammals Calne, Roy (GB) 1990-12-12 EP claimed