Sugi Predict

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SCHEMBL7187947

SCHEMBL7187947

COc1cc(OC)c(C(=O)c2ccccc2[P](=O)CC(C)C)c(OC)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 2/20 0.40
▸ ALDH1A1 P00352 1/20 0.39
▸ RAB9A P51151 3/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ USP2 O75604 2/20 0.39
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ SENP8 Q96LD8 1/20 0.39
▸ SENP7 Q9BQF6 1/20 0.39
▸ SENP6 Q9GZR1 1/20 0.39
▸ CYP3A4 P08684 3/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ PKM P14618 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ ATM Q13315 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ ABCG2 Q9UNQ0 1/20 0.37
▸ MAOA P21397 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187696 0.90 CA12 (0.41) ALDH1A1NPC1L3MBTL1KMT2ASMN1; SMN2
SCHEMBL7182907 0.89 TP53 (0.39) TP53ALDH1A1RAB9ANPC1USP2
SCHEMBL7179713 0.87 ALDH1A1 (0.36) TP53ALDH1A1RAB9ANPC1USP2
SCHEMBL7187186 0.83 CYP3A4 (0.40) TP53ALDH1A1RAB9ANPC1USP2
SCHEMBL7180883 0.83 ALDH1A1 (0.44) ALDH1A1L3MBTL1CYP3A4MAPK1TDP1
SCHEMBL7177678 0.81 L3MBTL1 (0.38) TP53ALDH1A1RAB9ANPC1USP2
SCHEMBL7189195 0.81 CNR2 (0.43) TP53ALDH1A1CYP3A4MAPT
SCHEMBL7184591 0.79 HTT (0.40) ALDH1A1NPC1KMT2ASMN1; SMN2HSD17B10
SCHEMBL7179788 0.78 HPGD (0.43) ALDH1A1KMT2ASMN1; SMN2MAPTMEN1
SCHEMBL7183698 0.78 CYP3A4 (0.40) TP53ALDH1A1RAB9ANPC1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TP53 3575/4885ALDH1A1 3416/4885RAB9A 1818/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TP53 3524/4885ALDH1A1 3984/4885RAB9A 2155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.