Sugi Predict

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SCHEMBL7182907

SCHEMBL7182907

COc1cc(OC)c(C(=O)c2ccccc2[P](=O)CCC(C)C)c(OC)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 2/20 0.39
▸ KMT2A Q03164 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ CYP3A4 P08684 3/20 0.37
▸ MAPT P10636 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ USP2 O75604 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ ABCG2 Q9UNQ0 1/20 0.36
▸ MAOA P21397 1/20 0.36
▸ MAOB P27338 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ PTPN1 P18031 1/20 0.36
▸ NPC1 O15118 2/20 0.36
▸ CASP3 P42574 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7184591 0.90 HTT (0.40) KMT2AALDH1A1HSD17B10SMN1; SMN2HTT
SCHEMBL7187947 0.89 TP53 (0.40) TP53KMT2AMEN1ALDH1A1CYP3A4
SCHEMBL7189195 0.84 CNR2 (0.43) TP53ALDH1A1CYP3A4MAPT
SCHEMBL7187186 0.82 CYP3A4 (0.40) TP53KMT2AMEN1ALDH1A1CYP3A4
SCHEMBL7179713 0.81 ALDH1A1 (0.36) TP53KMT2AMEN1ALDH1A1CYP3A4
SCHEMBL7177678 0.81 L3MBTL1 (0.38) TP53KMT2AMEN1ALDH1A1CYP3A4
SCHEMBL7180883 0.80 ALDH1A1 (0.44) ALDH1A1CYP3A4MAPK1L3MBTL1
SCHEMBL7189206 0.79 KMT2A (0.40) KMT2AMEN1ALDH1A1SMN1; SMN2HTT
SCHEMBL7187696 0.79 CA12 (0.41) KMT2AALDH1A1SMN1; SMN2HTTNPC1
SCHEMBL7181597 0.78 P2RX7 (0.36) KMT2AMEN1ALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TP53 3575/4885KMT2A 1586/4885MEN1 2312/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TP53 3524/4885KMT2A 956/4885MEN1 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.