Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189126 | 0.91 | ESR1 (0.46) | ESR1ESR2PPARGKDM4EALDH1A1 | |
| SCHEMBL7189323 | 0.90 | ESR1 (0.49) | ESR1ESR2 | |
| SCHEMBL7193070 | 0.86 | ESR1 (0.53) | ESR1ESR2 | |
| SCHEMBL7194900 | 0.85 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL7181194 | 0.84 | ESR1 (0.48) | ESR1ESR2KDM4E | |
| SCHEMBL7181203 | 0.84 | ESR1 (0.48) | ESR1ESR2KDM4E | |
| SCHEMBL7189250 | 0.83 | ESR1 (0.43) | ESR1ESR2KDM4EPTPN11 | |
| SCHEMBL7188897 | 0.83 | ESR1 (0.43) | ESR1ESR2KDM4EALDH1A1PTPN11 | |
| SCHEMBL7188421 | 0.83 | ESR1 (0.42) | ESR1ESR2GAA | |
| SCHEMBL7186100 | 0.83 | ESR1 (0.48) | ESR1ESR2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |