Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.43 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188897 | 0.94 | ESR1 (0.43) | ESR1ESR2EIF4A1PTPN11RARB | |
| SCHEMBL7193820 | 0.91 | ALOX5 (0.42) | ESR1ESR2EIF4A1KDM4ENPC1 | |
| SCHEMBL7186036 | 0.89 | ESR1 (0.49) | ESR1ESR2MAOA | |
| SCHEMBL7183821 | 0.88 | TDP1 (0.43) | ESR1ESR2PTPN11KDM4ENPC1 | |
| SCHEMBL7189999 | 0.85 | CYP4F2 (0.46) | ESR1ESR2KDM4ENPC1LMNA | |
| SCHEMBL7187213 | 0.85 | FFAR4 (0.47) | ESR1ESR2EIF4A1KDM4ENPC1 | |
| SCHEMBL7188063 | 0.84 | ESR1 (0.44) | ESR1ESR2MAOAALOX5 | |
| SCHEMBL7193824 | 0.84 | ESR1 (0.47) | ESR1ESR2NPC1LMNATP53 | |
| SCHEMBL7195079 | 0.84 | ESR1 (0.49) | ESR1ESR2MAOA | |
| SCHEMBL7182700 | 0.83 | ALDH1A1 (0.43) | ESR1ESR2NPC1RAB9AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |