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SCHEMBL7182641

SCHEMBL7182641

COc1ccc(Cl)c(OC)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C)cc(C(C)(C)C)cc1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.38
▸ ALDH1A1 P00352 4/20 0.36
▸ KDM4E B2RXH2 3/20 0.36
▸ LMNA P02545 2/20 0.36
▸ SMO Q99835 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ TAS1R3 Q7RTX0 2/20 0.35
▸ TAS1R1 Q7RTX1 2/20 0.35
▸ TAS1R2 Q8TE23 2/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ MAPT P10636 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ NR1H4 Q96RI1 2/20 0.35
▸ PPARG P37231 1/20 0.35
▸ PPARA Q07869 1/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ HPGD P15428 1/20 0.34
▸ NPY1R P25929 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7182502 0.91 TAS1R3 (0.41) ATMALDH1A1KDM4ESMOKMT2A
SCHEMBL7178067 0.88 ALDH1A1 (0.39) ATMALDH1A1KDM4ELMNASMO
SCHEMBL7188501 0.88 CYP1A2 (0.41) ATMALDH1A1KDM4ELMNASMO
SCHEMBL7189982 0.88 ALDH1A1 (0.37) ATMALDH1A1KDM4ELMNAKMT2A
SCHEMBL7174658 0.87 ATM (0.38) ATMALDH1A1KDM4ELMNASMO
SCHEMBL7189133 0.86 TAS1R3 (0.38) ATMALDH1A1KDM4ELMNAKMT2A
SCHEMBL7189530 0.84 ALDH1A1 (0.40) ATMALDH1A1KDM4ELMNASMO
SCHEMBL7187072 0.84 ALDH1A1 (0.43) ATMALDH1A1KDM4ESMOKMT2A
SCHEMBL7175435 0.84 ALDH1A1 (0.40) ATMALDH1A1KDM4ELMNASMO
SCHEMBL7182647 0.83 ALDH1A1 (0.39) ALDH1A1KDM4ELMNAKMT2ATAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ATM 2823/4885ALDH1A1 3416/4885KDM4E 3226/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ATM 2935/4885ALDH1A1 3984/4885KDM4E 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.