Sugi Predict

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SCHEMBL7188901

SCHEMBL7188901

Cc1c(C)c(C)c(C(=O)P(=O)(C(=O)c2c(Cl)cccc2Cl)c2ccccc2)c(C)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.39
▸ MAPT P10636 4/20 0.38
▸ PTK2B Q14289 1/20 0.38
▸ KMT2A Q03164 3/20 0.37
▸ LMNA P02545 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ USP2 O75604 1/20 0.37
▸ MT-CO2 P00403 1/20 0.37
▸ TTR P02766 1/20 0.37
▸ PLA2G1B P04054 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ PGR P06401 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ HTR1A P08908 1/20 0.37
▸ ADRA2A P08913 1/20 0.37
▸ ADORA3 P0DMS8 1/20 0.37
▸ AR P10275 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ HTR2A P28223 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7183064 0.93 TYK2 (0.42) ALDH1A1MAPTPTK2BKMT2ACYP2C9
SCHEMBL58730 0.90 ALDH1A1 (0.47) ALDH1A1MAPTPTK2BKMT2AUSP2
SCHEMBL7188861 0.90 MAPT (0.38) ALDH1A1MAPTPTK2BKMT2ALMNA
SCHEMBL7179727 0.88 CA12 (0.43) MAPTPTK2BKMT2AMEN1PTGS2
SCHEMBL7179862 0.88 TYK2 (0.44) ALDH1A1MAPTPTK2BKMT2ACYP2C9
SCHEMBL7174811 0.88 TYK2 (0.44) ALDH1A1MAPTPTK2BKMT2ACYP2C9
SCHEMBL7175604 0.87 MAPT (0.36) ALDH1A1MAPTPTK2BKMT2ALMNA
SCHEMBL7181151 0.87 TYK2 (0.39) ALDH1A1MAPTPTK2BKMT2ALMNA
SCHEMBL7182453 0.84 TYK2 (0.44) ALDH1A1MAPTPTK2BKMT2ACYP2C9
SCHEMBL7183686 0.84 TYK2 (0.40) ALDH1A1MAPTPTK2BKMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885MAPT 4870/4885PTK2B 1875/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885MAPT 4859/4885PTK2B 2406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.