Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189510

SCHEMBL7189510

SCHEMBL7189510

CC(CC(C(=O)c1c(C(F)(F)F)cccc1C(F)(F)F)c1ccccc1)P=O

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ AKR1C3 P42330 3/20 0.38
▸ AKR1C2 P52895 3/20 0.38
▸ ALDH1A1 P00352 3/20 0.37
▸ POLB P06746 3/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ EPHX2 P34913 3/20 0.36
▸ PPARG P37231 2/20 0.36
▸ ACP3 P15309 1/20 0.35
▸ TAS2R14 Q9NYV8 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ TXNRD1 Q16881 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189505 0.81 L3MBTL1 (0.40) ALDH1A1MEN1CYP1A2CYP3A4CYP2C9
SCHEMBL7187322 0.81 PPARG (0.39) ALDH1A1POLBMEN1CYP1A2CYP3A4
SCHEMBL7181409 0.80 KCNQ2 (0.44) ALDH1A1POLBMEN1KMT2A
SCHEMBL7184558 0.79 EPHX2 (0.37) ALDH1A1POLBMEN1CYP1A2CYP3A4
SCHEMBL7187933 0.78 CA12 (0.44) AKR1C3AKR1C2ALDH1A1POLBMEN1
SCHEMBL7175913 0.77 EPHX2 (0.36) ALDH1A1POLBMEN1CYP1A2CYP3A4
SCHEMBL7175788 0.76 ACP3 (0.41) AKR1C3AKR1C2ALDH1A1POLBMEN1
SCHEMBL7181408 0.76 NPSR1 (0.36) ALDH1A1MEN1KMT2ASMN1; SMN2HPGD
SCHEMBL7175839 0.76 KCNQ2 (0.40) L3MBTL1
SCHEMBL7175263 0.76 EPHX2 (0.35) ALDH1A1POLBMEN1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 AKR1C3 199/4885AKR1C2 305/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 AKR1C3 209/4885AKR1C2 294/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.